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Supriya Fatani
Mrs. Mamta Sharma
Dr. Mayank Bansal
Keywords:
Hippophae rhamnoides, Neuropharmacology, Antidepressant, Cognitive function, Wistar rats, Sea buckthorn.
Abstract:
Hippophae rhamnoides L. (sea buckthorn) is a medicinal plant widely recognized for its rich phytochemical composition and diverse pharmacological properties. The present review aims to provide a comprehensive overview of the neuropharmacological potential of Hippophae rhamnoides, particularly its antidepressant and cognitive protective effects in experimental models such as Wistar rats. Extensive literature suggests that the plant exhibits significant antioxidant, anti-inflammatory, neuroprotective, and adaptogenic activities. Behavioral studies including Forced Swim Test, Tail Suspension Test, and Morris Water Maze demonstrate its efficacy in reducing depressive-like symptoms and improving memory and learning. Mechanistically, the plant modulates monoaminergic neurotransmitters, enhances antioxidant defense systems, reduces neuroinflammation, and promotes neuroplasticity. The presence of bioactive compounds such as flavonoids, carotenoids, vitamins, and fatty acids contributes to its therapeutic effects. This review highlights the potential of Hippophae rhamnoides as a promising natural agent for the management of depression and cognitive disorders and provides insights for future pharmacological and clinical investigations.
Keywords: Hippophae rhamnoides, Neuropharmacology, Antidepressant, Cognitive function, Wistar rats, Sea buckthorn.
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International Journal of Recent Research and Review
ISSN: 2277-8322
Vol. XIX, Issue 1
March 2026
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PUBLISHED
March 2026
ISSUE
Vol. XIX, Issue 1
SECTION
Articles
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