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Pankaj Kumar
Dr. Lokesh Kumar Gautam
Dr. Vikas Agrawal
Dr. Manoj Kumar Gupta
Keywords:
Dexamethasone, Hydrogel, Oral film, Drug delivery, Bioavailability.
Abstract:
Dexamethasone is a potent corticosteroid widely used for the treatment of inflammatory and allergic conditions. However, conventional oral dosage forms suffer from first-pass metabolism, delayed onset of action, and reduced patient compliance, especially in pediatric and geriatric populations. The present review focuses on the formulation and evaluation of hydrogel-based oral films of dexamethasone as an innovative drug delivery system. Hydrogel-based oral films combine the advantages of hydrogels (high water retention, flexibility) and oral thin films (rapid disintegration, ease of administration). Various polymers such as HPMC, PVA, and sodium alginate are used for film formation, along with plasticizers and permeation enhancers. Evaluation parameters include thickness, folding endurance, swelling index, drug content, in vitro drug release, and stability studies. The hydrogel-based oral film system offers improved bioavailability, rapid onset of action, and enhanced patient compliance, making it a promising alternative to conventional dosage forms.
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International Journal of Recent Research and Review
ISSN: 2277-8322
Vol. XIX, Issue 1
March 2026
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PUBLISHED
March 2026
ISSUE
Vol. XIX, Issue 1
SECTION
Articles
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