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Rohit Bhiduri
Dr. Ashutosh Sharma
Dr. Mayank Bansal
Keywords:
Itraconazole, Deformable lipid vesicles, Transfersomes, Ethosomes, Antifungal therapy, Nanocarriers.
Abstract:
Itraconazole is a broad-spectrum triazole antifungal agent widely used in the treatment of systemic and superficial fungal infections. However, its clinical effectiveness is limited by poor aqueous solubility, low bioavailability, and variable pharmacokinetics. In recent years, deformable lipid vesicles (DLVs), including transfersomes and ethosomes, have emerged as promising nanocarriers for enhancing transdermal and topical drug delivery. These vesicular systems exhibit superior deformability, enabling them to penetrate the stratum corneum effectively and deliver drugs into deeper skin layers. The present review focuses on the formulation, characterization, and optimization of itraconazole-loaded deformable lipid vesicles as a novel strategy for antifungal therapy. Various formulation parameters such as lipid composition, surfactant concentration, ethanol content, and preparation methods are discussed in detail. Additionally, evaluation parameters including vesicle size, zeta potential, entrapment efficiency, deformability index, in vitro drug release, and skin permeation studies are critically reviewed. Optimization techniques such as factorial design and response surface methodology are also highlighted. This advanced delivery system offers improved bioavailability, targeted drug delivery, reduced systemic side effects, and enhanced therapeutic efficacy, making it a promising alternative to conventional antifungal formulations.
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International Journal of Recent Research and Review
ISSN: 2277-8322
Vol. XIX, Issue 1
March 2026
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PUBLISHED
March 2026
ISSUE
Vol. XIX, Issue 1
SECTION
Articles
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