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Al Arsh Raza
Dr. Sanjay Dhaker
Lakshita Bhati
Dr. Subhranshu Panda
Keywords:
Smart polymers, Matrix tablets, Sustained drug delivery, Controlled release, Oral drug delivery, Hydrophilic polymers, Drug release kinetics.
Abstract:
Oral sustained drug delivery systems have become an integral component of modern pharmaceutical formulation owing to their ability to maintain therapeutic drug concentrations for prolonged periods, reduce dosing frequency, and improve patient compliance. Among various sustained-release dosage forms, matrix tablets are widely employed because of their simple manufacturing process, cost-effectiveness, and versatility in delivering a broad range of therapeutic agents. In recent years, the incorporation of smart polymers into matrix tablet formulations has significantly enhanced their performance by enabling controlled and stimuli-responsive drug release. Smart polymers can alter their physicochemical properties in response to environmental stimuli such as pH, temperature, ionic strength, enzymes, or electric and magnetic fields, thereby improving drug bioavailability and therapeutic efficacy. Both natural polymers (chitosan, sodium alginate, guar gum, xanthan gum), semi-synthetic polymers (hydroxypropyl methylcellulose and sodium carboxymethyl cellulose), and synthetic polymers (Carbopol®, Eudragit®, polyvinyl alcohol, polyethylene oxide) are extensively utilized in sustained-release formulations. Recent advances in nanotechnology, three-dimensional printing, artificial intelligence-assisted formulation optimization, and Quality by Design (QbD) approaches have further accelerated the development of intelligent oral drug delivery systems. This review summarizes the principles of sustained drug delivery, matrix tablet technology, smart polymers, formulation strategies, drug release mechanisms, manufacturing methods, evaluation parameters, recent developments, and future prospects in oral sustained drug delivery.
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International Journal of Recent Research and Review
ISSN: 2277-8322
Vol. XIX, Issue 2
June 2026
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PUBLISHED
June 2026
ISSUE
Vol. XIX, Issue 2
SECTION
Articles
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