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Divesh Nagar
Dr. Abhishek Nagar
Keywords:
Luliconazole; Nanoemulgel; Topical Drug Delivery; Antifungal Therapy; Carbopol 940; HPMC; Coconut Oil; Drug Release Kinetics; Korsmeyer-Peppas Model; Stability Studies; Skin Permeation; Fungal Infections
Abstract:
The present study was aimed at the formulation and evaluation of a Luliconazole-loaded nanoemulgel for effective topical treatment of fungal skin infections. Nanoemulgel formulations were prepared using different concentrations of HPMC, Carbopol 940, coconut oil, Tween 80, and other suitable excipients to enhance drug solubility, skin penetration, and therapeutic efficacy. Preformulation studies, including melting point determination, solubility analysis, Differential Scanning Calorimetry (DSC), Fourier Transform Infrared Spectroscopy (FTIR), and UV spectrophotometric analysis, confirmed the purity and compatibility of Luliconazole with the selected formulation components. Nine formulations (F1-F9) were developed and evaluated for pH, viscosity, spreadability, extrudability, drug content, and in vitro drug release. The formulations exhibited acceptable physicochemical properties with pH values ranging from 6.8 to 7.5, indicating suitability for topical application. Among all formulations, F8 demonstrated optimum performance with satisfactory spreadability, excellent extrudability, and enhanced drug release characteristics. Drug release kinetic studies revealed that the release pattern followed the Korsmeyer-Peppas model, indicating a diffusion-controlled release mechanism. Stability studies confirmed that the optimized formulation remained physically and chemically stable under different storage conditions. The developed Luliconazole nanoemulgel showed promising potential as an effective topical drug delivery system, offering improved drug release, enhanced bioavailability, prolonged retention, and better patient compliance for the management of fungal infections.
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International Journal of Recent Research and Review
ISSN: 2277-8322
Vol. XIX, Issue 2
June 2026
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PUBLISHED
June 2026
ISSUE
Vol. XIX, Issue 2
SECTION
Articles
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