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Mohit sharma
Mr. Puneet Gupta
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Keywords:
Etoricoxib; orally disintegrating tablet; mouth-dissolving film; Pullulan; crospovidone; direct compression; solvent casting; disintegration; drug release; oral drug delivery.
Abstract:
Background: Etoricoxib is a selective cyclooxygenase-2 inhibitor used for the management of pain and inflammation. Conventional oral tablets may be inconvenient for patients who have difficulty swallowing and may not provide the rapid disintegration desired for fast-onset oral delivery. The supplied thesis investigated two rapid-release dosage forms: orally disintegrating tablets (ODTs) and mouth-dissolving films (MDFs).
Methods: Etoricoxib ODTs (F1–F9) were prepared by direct compression using microcrystalline cellulose, mannitol and crospovidone with taste-masking and lubrication excipients. MDFs (F1-F9) were developed by solvent casting using film-forming polymers, principally Pullulan, with PEG 400 as a plasticizer and additional formulation components. Preformulation, micromeritic, physicochemical, disintegration, drug-content, dissolution, FTIR, DSC and stability assessments were described in the thesis.
Results: The thesis-reported ODTs showed tablet weights of 244.5-245.4 mg, thickness of 3.16–3.20 mm, hardness of 3.6-5.1 kg/cm² and friability of 0.45-0.62%. Disintegration times were 12–24 s, with F5 at 14 s and F6 at 12 s. ODT drug content ranged from 92.1-99.2%, while 30-min drug release ranged from 72.4-98.1%. MDF thickness increased from 0.118 to 0.214 mm across F1–F9, and disintegration times ranged from 11-32 s. MDF drug content ranged from 91.8-99.8%, and 30-min drug release ranged from 86.4-99.7%. The thesis selected F5 as the optimized formulation for comparative discussion, although F6 showed the shortest disintegration time in both dosage-form series.
Conclusion: Both dosage-form approaches demonstrated rapid in-vitro disintegration and drug release in the thesis dataset. ODT F5 showed 14-s disintegration, 99.2% drug content and 98.1% release at 30 min, whereas MDF F5 showed 14-s disintegration, 99.8% drug content and 99.1% release at 30 min. These findings support further experimental optimization, taste evaluation, long-term stability testing, scale-up and in-vivo performance assessment. Because selected values are explicitly described as illustrative in the thesis, final publication should use the original laboratory dataset and recalculated statistics.
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International Journal of Recent Research and Review
ISSN: 2277-8322
Vol. XIX, Issue 3
September 2026
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PUBLISHED
September 2026
ISSUE
Vol. XIX, Issue 3
SECTION
Articles
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